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KMID : 0383119580060010017
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Journal of Aerospace Medicine
1958 Volume.6 No. 1 p.17 ~ p.33
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THE STUDIES ON THE RESISTANCE OF STAPHYLOCOCCUS AUREUS, STRAIN 209-P, TO ERYTHROMYCIN
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최재위:
오창열:Oh Chang-Yul
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Abstract
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The followings were resulted from the observations on transferring at slant media containing serial concentration of erythromycin and from the mechanisms of resistance developing by continuous transferring of resistant strain to low Erythromycin concentration along with the study on the pattern of resistance developing in vivo.
1. Strain 209-P always showed constant resistance distribution to erythromycin
2. Strain. 209-P was inhibited half of the total population at 0.39r of erythromycin, markedly at 0.78 r and completely at 3.12r.
3. All of the resistant population survived lower concentration developed resistance slowly at the beginning of transfer and rapidly after passed through a definite generation In the development of resistance of all population, the duration of contact with erythromycin during the cleavage and reproduction is appar-
ently important determination factor than contacting concentration of erythromycin is.
4. Under the low concentration of Erythromycin, resistant strain to low concentration of strong growth rate act important role in resistance development but resistant strain to high concentration do under the high concentration of f Erythromycin and rather rapidly develop than former strain.
5. The rate of developing resistance was much more rapid in back mutant compared with stock strains.
6. No increasing resistance was noted in the so called rosting cells.
The development of resistance to erythromycin in strain 209-P is supposed to depend upon mutation explicable by "Spontaneous mutation and selection Adaptation" which is originated from the contacts with erythromycin during cleaving and reproductive procedure or in condition of active growth of bacteria selected by the antibiotics.
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KEYWORD
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